产品货号：
Z32004
中文名称：
Cdh1/FZR1抗体
英文名称：
Anti-Cdh1/FZR1 Antibody (Clone#1621CT637.76.67)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Cdh1/FZR1 Antibody (Clone#1621CT637.76.67) |
| 指标别名 | CDC20 like protein 1;CDC20C;CDH1;Cdh1/Hct1 homolog;Fizzy related protein homolog;FYR;FZR;FZR1;FZR2;HCDH;HCDH1;KIAA1242 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | FZR1 |
| 克隆号 | 1621CT637.76.67 |
| 抗体来源 | Mouse |
| 免疫原 | This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR. |
| 计算分子量 | 55kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C),which confers substrate specificity upon the complex.Associates with the APC/C in late mitosis,in replacement of CDC20,and activates the APC/C during anaphase and telophase.The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely.At the G1/S transition FZR1 is phosphorylated,leading to its dissociation from the APC/C.Following DNA damage,it is required for the G2 DNA damage checkpoint:its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1,preventing entry into mitosis. |
| Uniprot ID | Q9UM11 |
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